The Potential of Endothelial Colony-Forming Cells to Improve Early Graft Loss after Intraportal Islet Transplantation

Thioredoxin-1 Attenuates Early Graft Loss after Intraportal Islet Transplantation in Mice

AIMS Recent studies suggest that decreasing oxidative stress is crucial to achieve successful islet transplantation. Thioredoxin-1 (TRX), which is a multifunctional redox-active protein, has been reported to suppress oxidative stress. Furthermore, it also has anti-inflammatory and anti-apoptotic effects. In this study, we investigated the effects of TRX on early graft loss after islet transplan...

Thrombomodulin improves early outcomes after intraportal islet transplantation.

Primary islet nonfunction due to an instant blood mediated inflammatory reaction (IBMIR) leads to an increase in donor islet mass required to achieve euglycemia. In the presence of thrombin, thrombomodulin generates activated protein C (APC), which limits procoagulant and proinflammatory responses. In this study, we postulated that liposomal formulations of thrombomodulin (lipo-TM), due to its ...

Effect of intraportal human islet transplantation on kidney graft survival in simultaneous kidney-islet allografts.

Intrapancreatic islet transplantation as a potential solution to chronic failure of intraportal islet grafts.

Pancreatic Islet Transplantation Modifications of Islet Properties to Improve Graft Survival